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Vitamin C is also a cofactor for several Jumonji C domain-containing histone demethylases (JHDM) that catalyze histone demethylation (Klose et al., 2006)

Zhang et al., 2019), and cystine starvation can impair growth in multiple in-vivo cancer models (Cramer et al., 2017

EVs in the regulation of glucose metabolism Glucose metabolism is a central component of cellular metabolic activity, which involves key processes such as glycolysis, the tricarboxylic acid (TCA) cycle, and OXPHOS [52]

Mori et al., 2014), contributing to more than 85% of NAD + synthesis (Frederick et al., 2016)

[DOI] [PMC free article] [PubMed] [Google Scholar] 24.McMahon G.M., Hwang S.-J., Tanner R.M., Jacques P.F., Selhub J., Muntner P., Fox C.S